June Research Update

For the past month, I have been working on¬†expressing my mutant thyroid hormone receptor A382PfsX7 and a wild-type TRa1 within HeLa cells. (What are “HeLa” cells? An immortal human cell line often used in scientific research. These cells were derived from Henrietta Lacks, who died of cancer back in 1951.) This process requires that I […]

Abstract: Characterizing the Subcellular Localization of Mutant TRa1 (Ala382ProfsX7)

Passero, Kristin, 2

Thyroid hormone (TH) is received by thyroid hormone receptors (TRs), resulting in ligand-dependent interactions with TH-target genes. There are multiple forms of TRs which are expressed in different tissues; the TRa1 subtype is found predominantly in the central nervous system, bone, the gastrointestinal tract, and cardiac/skeletal muscle (Moran et al., 2013). Ala382ProfsX7 is a novel […]