Abstract: Recreating a model of the oscillatory dynamics of the rat locus coeruleus through early infancy

Mammals cycle between the states of sleep and wakefulness, and the dynamics of sleep-wake cycles in infant mammals are especially interesting, as they greatly differ from those of adult mammals. In infants, this cycling is more rapid and is exponentially distributed. These states are associated with populations of neurons that are specific to each state. The development of the locus coeruleus (LC), a brainstem structure, in infant rats has an evident impact on their sleep-wake cycles. In a paper written by Patel  et al in 2015, the authors developed a model of the neuronal interactions in the rat LC. This summer, I will be recreating this model in order to gain an in-depth understanding of how it was developed. This project will be in preparation for my senior thesis work which will expand upon this model.

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